Title : Beneficial effects of mesenchymal stem cell derived exosomes on Induced Multiple Sclerosis in Dogs
Abstract:
Multiple sclerosis (MS) is a multifocal demyelinating disease that leads to irreversible neurodegeneration. Over the past several decades, many animal models were developed in order to understand variety of aspects of MS. Exosomes generated from stem cells have demonstrated significant potential for neurological disorders because they contain growth factors, a complex set of miRNA, enzymes, proteins, large peptides, lipids, and macromolecules with anti-inflammatory, angiogenesis, and neurogenesis activity. The purpose of this study was to assess the healing potential of stem cell-derived Exosomes for the treatment of an experimentally induced MS dog model. Exosomes were administered intravenously to dog models of MS, and the therapy process was evaluated clinically, radiologically, histopathologically, and electron microscopy, as well as cerebrospinal fluid analysis. Results revealed that treated groups significantly improved their clinical indicators when compared to control groups, and histology, electron microscopy, and magnetic resonance imaging all demonstrated significant healing and remyelination in treated groups at the conclusion of the trial. Exosomes have proven to be effective and safe important actors in myelin regeneration, and their use can help stimulate remyelination in diseases like MS.
Audience take away:
- The presentation offers a new treatment modality to one of the most aggressive demyelinating neurological disorders like MS affecting animals and humans.
- The Audience will benefit from the study design and the clear research methodology and results.
- The approach used in this research offers a practical solution for Neurological disorders as cell free regenerative therapy.
- This treatment can be used either for clinicians or for researchers.
